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Publications

Selected reviews:

  1. Gouras GK, Olsson TT, Hansson O. β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease. Neurotherapeutics, 12(1): 3–11, 2015.
  2. Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E. Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease. ACTA Neuropathologica, 119(5):523-41, 2010.


Selected primary research articles (in reverse chronological order):

  1. Prion-like seeding and nucleation of intracellular amyloid-β. Olsson TT, Klementieva O, Gouras GK. Neurobiol Dis. 2018 May;113:1-10.
  2. Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses. Willén K, Sroka A, Takahashi RH, Gouras GK. J Alzheimers Dis. 2017;60(2):511-524.
  3. Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A. Willén K, Edgar JR, Hasegawa T, Tanaka N, Futter CE, Gouras GK. Mol Neurodegener. 2017 Aug 23;12(1):61.
  4. Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP. Klementieva O, Willén K, Martinsson I, Israelsson B, Engdahl A, Cladera J, Uvdal P, Gouras GK. Nat Commun. 2017 Mar 13;8:14726.
  5. ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation. Edgar JR, Willén K, Gouras GK, Futter CE. J Cell Sci. 2015 Jul 15;128(14):2520-8.
  6. Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses. Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK. PLoS One. 2013;8(1):e51965.
  7. Impaired β-amyloid secretion in Alzheimer's disease pathogenesis. Tampellini D, Rahman N, Lin MT, Capetillo-Zarate E, Gouras GK. J Neurosci. 2011 Oct 26;31(43):15384-90.
  8. High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils. Capetillo-Zarate E, Gracia L, Yu F, Banfelder JR, Lin MT, Tampellini D, Gouras GK. Am J Pathol. 2011 Nov;179(5):2551-8.
  9. Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice. Tampellini D, Capetillo-Zarate E, Dumont M, Huang Z, Yu F, Lin MT, Gouras GK. J Neurosci. 2010 Oct 27;30(43):14299-304.
  10. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK. PLoS One. 2010 Sep 20;5(9).
  11. Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gou
  12. Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses. Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK. Neurobiol Aging. 2010 Jul;31(7):1145-52.
  13. Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Tampellini D, Magrané J, Takahashi RH, Li F, Lin MT, Almeida CG, Gouras GK. J Biol Chem. 2007 Jun 29;282(26):18895-906.
  14. Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. Almeida CG, Takahashi RH, Gouras GK. J Neurosci. 2006 Apr 19;26(16):4277-88.
  15. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, Gouras GK. Neurobiol Dis. 2005 Nov;20(2):187-98.
  16. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK. J Neurochem. 2004 Jun;89(5):1308-12.
  17. Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK. J Neurosci. 2004 Apr 7;24(14):3592-9.
  18. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK. Am J Pathol. 2002 Nov;161(5):1869-79.
  19. Intraneuronal Abeta42 accumulation in human brain. Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR. Am J Pathol. 2000 Jan;156(1):15-20.
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