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Biosketch - Gunnar Gouras

Gunnar Keppler Gouras (GK Gouras, G Gouras in papers) received his doctorate in medicine from Columbia University (1989), neurology residency training from Harvard Medical School (1995), fellowship training in behavioral neurology and dementia at Cornell University Medical College (1997), and postdoctoral research training at Johns Hopkins University School of Medicine, Cornell University Medical College and Rockefeller University. He received an NIH KO8 clinical scientist development award at Rockefeller in 1999 with Paul Greengard (Nobel laureate, 2000) as his mentor. In 2008 Dr. Gouras was promoted to professor of neurology and neuroscience at Weill Cornell Medical College in New York, NY. In 2011 he was appointed Professor of Experimental Neurology and head of the Experimental Dementia Research Unit in the Department of Experimental Medical Science in the Faculty of Medicine at Lund University. Since 2012, he is head of the Neurobiology section and since 2015 coordinator of the Multidisciplinary Research Environment on Parkinson’s disease and related disorders MultiPark at Lund University. He is also coordinator of the EU Horizon 2020 Marie Skłodowska-Curie ITN consortium SynDegen.

The focus of his lab is to elucidate the mechanism(s) of early synapse dysfunction in Alzheimer’s disease (AD) and related neurodegenerative disorders. His group was the first to report on: intraneuronal β-amyloid (Aβ) accumulation in Down syndrome and AD; accumulation of Aβ in endosomes and synapses in AD; Aβ-dependent reduction in glutamate receptors and PSD-95 at synapses, and Aβ-dependent impairment in the ubiquitin proteasome system and in the multivesicular body (MVB) sorting pathway in AD primary neuron models; and the requirement of Aβ antibody internalization into neurons as a mechanism for Aβ reduction and synaptic protection in Aβ immunotherapy for AD.

Past honors include the Paul Beeson Physician Scholars in Aging Research award (2000) from the American Federation for Aging Research, the Merck Young Investigator Award in Alzheimer’s disease from the American Academy of Neurology (2001), and Temple (2003) and Zenith (2007) awards from the Alzheimer’s Association.
He is member of several editorial boards, including ACTA Neuropathologica (2009-) and Neurobiology of Aging (2015-).
For publications listing see Gouras G in PubMed; for citations see Gunnar Keppler Gouras in Google Scholar; ORCID - ID is 0000-0002-5500-6325.